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Thursday, January 11, 2018
Aluminum Adjuvant Causes Brain Inflammation and Behavioral Abnormalities; Low Dose Is More Harmful
A new paper (Crepeaux et al.) by the Gherardi research group in France reports important results on the toxicity and transport of aluminum (Al) adjuvant in mice. This study is especially valuable because it looked at many outcomes: behavioral effects, immune (microglial) activation in the brain, and Al transport into the brain. The study tested dosages of 200 , 400 and 800 mcg/Kg (mcg=micrograms, mcg/Kg = micrograms per kilogram of animal body weight), injected intramuscularly (IM). The Al adjuvant used was AlOH (brand name Alhydrogel), the most commonly used vaccine adjuvant. It is in the tetanus, Hep A, Hep B, HiB, pneumococcal, meningococcal, and anthrax vaccines.
Remarkably, the study found that the lowest dosage (200 mcg/Kg) was the most toxic! The 400 and 800 mcg/Kg dosages produced no statistically significant effects, but the 200 mcg/Kg dosage did.